반응 #870

반응 방정식

N-benzyloxycarbonyl-β-benzyl-L-aspartyl-D-valine (R)-α-methoxymethylbenzylamide

→

α-L-aspartyl-D-valine (R)-α-methoxymethylbenzylamide

수율 70.1%

용매

methanol

water

반응 조건

후처리

1. 1
   기타The catalyst was removed by filtration
2. 2
   농축the resulting filtrate was concentrated under reduced pressure to 15 ml
3. 3
   기타The crystal thus precipitated
4. 4
   기타was removed by filtration
5. 5
   기타dried

실험 절차

To a suspension of 6.20 g (10.5 mmols) of N-benzyloxycarbonyl-β-benzyl-L-aspartyl-D-valine (R)-α-methoxymethylbenzylamide in 200 ml of methanol and 50 ml of water was added 1.50 g of 10% Pd-carbon (water content 50%). The mixture was reduced under hydrogen under heat at 40° C. The catalyst was removed by filtration, and the resulting filtrate was concentrated under reduced pressure to 15 ml. The crystal thus precipitated was removed by filtration and dried to obtain 2.69 g (7.36 mmols, 70.0% ) of α-L-aspartyl-D-valine (R)-α-methoxymethylbenzylamide.

출처