반응 #869

반응 방정식

HCl dioxane

N-t-butoxycarbonyl-(R)-α-methoxymethylbenzylamine

→

(R)-α-methoxymethylbenzylamine hydrochloride

반응 조건

후처리

1. 1
   농축The reaction mixture was concentrated under reduced pressure
2. 2
   workup.ADDITION30 ml of ether were added to the residue
3. 3
   농축this was further concentrated

실험 절차

60 ml of 4N-HCl/dioxane solution was added to 4.02 g (16.0 mmols) of N-t-butoxycarbonyl-(R)-α-methoxymethylbenzylamine, and the mixture was stirred at room temperature for one hour. The reaction mixture was concentrated under reduced pressure. 30 ml of ether were added to the residue, and this was further concentrated to obtain (R)-α-methoxymethylbenzylamine hydrochloride in quantitative yield.

출처