반응 #8688

반응 방정식

2-phenylethanesulfonyl chloride

ammonia

HCl

→

2-phenyl-ethanesulfonic acid amide

용매

THF

반응 조건

후처리

1. 1
   기타the organic solvent was evaporated
2. 2
   workup.ADDITIONThe remaining suspension was diluted with water
3. 3
   추출extracted four times with EA
4. 4
   기타evaporated

실험 절차

A solution of 2-phenylethanesulfonyl chloride (40.94 g) in THF (250 ml) was cooled to −20° C. before it was treated with sat. aq. ammonia (50 ml). The brown suspension was stirred at rt for 16 h. The mixture was neutralised with aq. HCl and the organic solvent was evaporated. The remaining suspension was diluted with water and extracted four times with EA. The organic layers were combined and evaporated to give 2-phenyl-ethanesulfonic acid amide (33.06 g) as orange solid. 1H-NMR(300 MHz, CDCl3): 3.15–3.21(m, 2H), 3.38–3.45(m, 2H), 4.59(s br, 2H), 7.21–7.37(m, 5H).

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