반응 #86640

ord-80e86ca51fe94179817a5886ec0c88da

반응 방정식

C=CCOc1ccc(C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)OC)cc1
Methyl ester
C=CCOc1ccc(C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)OC)cc1
(S)-2-[(S)-3-(4-Allyloxy-phenyl)-2-tert-butoxycarbonylamino-propionylamino]-4-methyl-pentanoic acid methyl ester
Cl
HCl
→
C=CCOc1ccc(C[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)OC)cc1.Cl
(S)-2-[(S)-3-(4-Allyloxy-phenyl)-2-amino-propionylamino]-4-methyl-pentanoic acid methyl ester hydrogen chloride salt

반응물

C=CCOc1ccc(C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)OC)cc1
Methyl ester
C=CCOc1ccc(C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)OC)cc1
(S)-2-[(S)-3-(4-Allyloxy-phenyl)-2-tert-butoxycarbonylamino-propionylamino]-4-methyl-pentanoic acid methyl ester
Cl
HCl
—
resultant solution

시약

없음

용매

C1COCCO1
1,4-dioxane

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    농축before being concentrated in vacuo
  2. 2
    기타to yield a white solid, 3.43 g, 100%

실험 절차

Methyl ester 1 (4.00 g, 8.92 mmol) was dissolved in 4M HCl in 1,4-dioxane (20 mL). The resultant solution was stirred at rt for 18 h before being concentrated in vacuo to yield a white solid, 3.43 g, 100%.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US09434762B2uspto-grants-2016_09