반응 #86503

반응 방정식

2-(1-bromopropyl)-3-iodo-6-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

sodium azide

→

crude product

2-(1-azidopropyl)-3-iodo-6-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

용매

ethyl acetate

DMF

반응 조건

후처리

1. 1
   세척the mixture was washed with water, brine
2. 2
   건조dried over sodium sulfate
3. 3
   기타evaporated under reduced pressure

실험 절차

A mixture of 2-(1-bromopropyl)-3-iodo-6-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (4.50 g, 11.0 mmol) and sodium azide (3.59 g, 55.3 mmol) in DMF was stirred at room temperature for 2 h. After diluting with ethyl acetate, the mixture was washed with water, brine, dried over sodium sulfate, and evaporated under reduced pressure to provide the crude product, which was used directly in next step (3.35 g, 82.1%). LCMS calculated for C12H13IN5O (M+H)+: m/z=370.0. Found: 370.2.

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