반응 #86500

반응 방정식

bromine

methyl 3-oxohexanoate

→

desired compound

methyl 4-bromo-3-oxohexanoate

용매

chloroform

chloroform

반응 조건

후처리

1. 1
   기타at 0° C.
2. 2
   온도to warm to room temperature overnight
3. 3
   workup.STIRRINGWhile stirring
4. 4
   기타a stream of air was bubbled through the solution for 1 hour
5. 5
   건조The reaction mixture was dried over sodium sulfate
6. 6
   기타the solvent evaporated under reduced pressure

실험 절차

Under a nitrogen atmosphere, a solution of bromine (8.61 mL, 167 mmol) in chloroform (20 mL) was added drop-wise over a period of 2 h to a solution of methyl 3-oxohexanoate (Fluka, 24.1 g, 167 mmol) in chloroform (147 mL), at 0° C. (ice bath). The reaction mixture was stirred for 30 min at 0° C. and then allowed to warm to room temperature overnight. While stirring, a stream of air was bubbled through the solution for 1 hour. The reaction mixture was dried over sodium sulfate and the solvent evaporated under reduced pressure to provide the desired compound.

출처