반응 #8650

ord-7699baaddd76414b851d402dc61a2e83

반응 방정식

CCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1.O=C(O)CC(O)(CC(=O)O)C(=O)O
fentanyl citrate
COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)O
aspartame
OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
mannitol
→
CCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1
Fentanyl

반응물

CCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1.O=C(O)CC(O)(CC(=O)O)C(=O)O
fentanyl citrate
COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)O
aspartame
OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
mannitol

시약

없음

용매

O
water
O
water

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    workup.ADDITIONby mixing thoroughly in the bowl of a vacuum mixer
  2. 2
    온도The mix was then heated to 40° C.±2° C.
  3. 3
    workup.DISSOLUTIONdissolution of the solids
  4. 4
    온도When cooled
  5. 5
    workup.STIRRINGThe mix was then homogenized
  6. 6
    workup.DISSOLUTIONdissolution of the solids
  7. 7
    workup.ADDITIONthe bulk mix
  8. 8
    workup.STIRRINGhomogenized
  9. 9
    workup.DISSOLUTIONdissolution

실험 절차

Gelatin (765 g) and mannitol (540 g) were dispersed in a portion of purified water (16 kg) by mixing thoroughly in the bowl of a vacuum mixer. The mix was then heated to 40° C.±2° C. and homogenised for ten minutes to allow complete dissolution of the solids. The mix was cooled down to room temperature (20–24° C.). When cooled, the fentanyl citrate (22.68 g), the aspartame (90 g), and mint flavour (90 g) were added sequentially to the mix. The mix was then homogenized to ensure complete dissolution of the solids. The remaining water (492 g) was added to the mixer and the bulk mix homogenized to ensure dissolution was complete.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07090866B2uspto-grants-2006_08