반응 #86472

반응 방정식

TFA

tert-butyl (4-(4-isopropylpiperazin-1-yl)-2-nitrophenyl)carbamate

→

title compound

수율 115.0%

4-(4-isopropylpiperazin-1-yl)-2-nitroaniline

수율 115.0%

용매

DCM

반응 조건

후처리

1. 1
   기타The resulting reaction mixture
2. 2
   기타Reaction progress
3. 3
   기타after completion of the reaction, excess solvents
4. 4
   기타were removed under reduced pressure
5. 5
   기타to afford a crude residue
6. 6
   세척The crude residue was repeatedly washed with ether

실험 절차

TFA (3 mL) was slowly added to a stirred solution of tert-butyl (4-(4-isopropylpiperazin-1-yl)-2-nitrophenyl)carbamate (1.2 g, 3.29 mmol) in dry DCM (5 mL) under argon atmosphere at 0° C. The resulting reaction mixture was allowed to warm to room temperature and stirred for 12 hr. Reaction progress was monitored by LCMS, after completion of the reaction, excess solvents were removed under reduced pressure to afford a crude residue. The crude residue was repeatedly washed with ether to get the title compound (1 g, yield: 80.6%) as a red solid. MS (ESI): 265.1 [M+H]+.

출처