반응 #86344

반응 방정식

2-(4-bromo-3,5-dimethyl-1H-pyrazol-1-yl)acetic acid

azetidin-3-ol

HOBt

EDC

N-ethyl-N-isopropylpropan-2-amine

→

title compound

2-(4-bromo-3,5-dimethyl-1H-pyrazol-1-yl)-1-(3-hydroxyazetidin-1-yl)ethanone

용매

EtOAc

DMF

반응 조건

후처리

1. 1
   기타The crude reaction mixture
2. 2
   세척washed with brine
3. 3
   건조dried over Na2SO4
4. 4
   농축concentrated

실험 절차

To 2-(4-bromo-3,5-dimethyl-1H-pyrazol-1-yl)acetic acid (0.4 g, 1.716 mmol) in DMF (6 mL) were added azetidin-3-ol (0.151 g, 2.060 mmol), HOBt (0.301 g, 2.231 mmol), and EDC (0.461 g, 2.403 mmol), followed by N-ethyl-N-isopropylpropan-2-amine (1.495 mL, 8.58 mmol). The reaction mixture was stirred for 18 hours at room temperature. The crude reaction mixture was subsequently diluted with EtOAc, washed with brine, dried over Na2SO4, and concentrated to give the title compound, which was used without further purification.

출처