반응 #86306

반응 방정식

D,L-isoleucyl-L-proline benzyl ester hydrochloride

DIEA

benzoyl chloride

→

oil

수율 79.0%

N-benzoyl-D,L-isoleucyl-L-proline benzyl ester

수율 79.0%

용매

dichloromethane

반응 조건

후처리

1. 1
   온도to warm up naturally to room temperature
2. 2
   기타to react for 2 h
3. 3
   농축concentrated under reduced pressure
4. 4
   기타to remove the solvent
5. 5
   기타purified on a column

실험 절차

D,L-isoleucyl-L-proline benzyl ester hydrochloride (1.2 g) was dissolved in dichloromethane (10 ml), cooled down to 0° C., and DIEA (860 mg) and benzoyl chloride (477 mg) were added dropwisely. The resulting mixture was allowed to warm up naturally to room temperature to react for 2 h, concentrated under reduced pressure to remove the solvent, and purified on a column to give a pale yellow oil (1.1 g, 79%).

출처