반응 #86242

반응 방정식

2-bromo-6-fluoropyridine

1,4-diazepan-6-ol

DIPEA

→

1-(6-Bromopyridin-2-yl)-1,4-diazepan-6-ol

용매

EtOH

반응 조건

후처리

1. 1
   기타After completion of the reaction, it
2. 2
   농축was concentrated under reduced pressure
3. 3
   기타The crude material was used in the next step without further purification

실험 절차

To a mixture of 2-bromo-6-fluoropyridine (845 mg, 4.83 mmol) and 1,4-diazepan-6-ol (560 mg, 4.83 mmol) in EtOH (20 mL) was added DIPEA (5 mL). The reaction mixture was heated at 100° C. for 15 hours, which was monitored by LCMS. After completion of the reaction, it was concentrated under reduced pressure. The crude material was used in the next step without further purification. MS (ESI) m/z: 272 [M+H]+.

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