반응 #8622

반응 방정식

3-[1-[2-amino-3-(4-fluorophenyl)proponyl]-4-(2-naphthalen-2-ylethyl)-5-oxo-piperazin-2-yl]propionitrile

N-acetyl-L-tyrosine

1-hydroxybenzotriazole

N-methylmorpholine

1-(3-dimethylaminopropyl)-3-ethylcarbodiimide

→

crude product

2-acetylamino-N-[2-[2-(2-cyanoethyl)-4-(2-naphthalen-2-ylethyl)-5-oxo-piperazin-1-yl]-1-(4-fluorobenzyl)-2-oxo-ethyl]-3-(4-hydroxyphenyl)-propionamide

용매

DMF

water

반응 조건

후처리

1. 1
   온도to warm
2. 2
   workup.STIRRINGstir at room temperature another 2 hours
3. 3
   여과the resulting solid is collected by filtration
4. 4
   workup.DISSOLUTIONre-dissolved in EtOAc
5. 5
   추출extracted with water
6. 6
   기타dried
7. 7
   농축concentrated in vacuo

실험 절차

To a solution of 3-[1-[2-amino-3-(4-fluorophenyl)proponyl]-4-(2-naphthalen-2-ylethyl)-5-oxo-piperazin-2-yl]propionitrile, 33, (47.2 g, 100 mmol), N-acetyl-L-tyrosine (22.3 g, 120 mmol), 1-hydroxybenzotriazole (16.2 g, 120 mmol), and N-methylmorpholine (132 mL, 120 mmol) in DMF (150 mL) is cooled to 0° C. and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (24.9 g, 130 mmol) is slowly added. The resulting mixture is stirred for 2 hours at 0° C. then allowed to warm and stir at room temperature another 2 hours. The reaction solution is diluted with water and the resulting solid is collected by filtration, re-dissolved in EtOAc and extracted with water, dried and concentrated in vacuo to afford the crude product which is purified over silica gel.

출처