반응 #86105

반응 방정식

trimethyl-[2-[[6-(5-vinyl-3-pyridyl)pyrazolo[4,3-c]pyridin-1-yl]methoxy]ethyl]silane

Hydrogen

→

2-[[6-(5-ethyl-3-pyridyl)pyrazolo[4,3-c]pyridin-1-yl]methoxy]ethyl-trimethyl-silane

수율 27.0%

용매

Ethanol

반응 조건

후처리

1. 1
   여과The mixture was filtered through Celite
2. 2
   농축The filtrate was concentrated
3. 3
   기타The residue was purified on silica
4. 4
   세척eluted with 0 to 5% MeOH in DCM

실험 절차

To a solution of trimethyl-[2-[[6-(5-vinyl-3-pyridyl)pyrazolo[4,3-c]pyridin-1-yl]methoxy]ethyl]silane (543.4 mg) in Ethanol (50 mL) in a 250 mL round bottom flask was added Pearlman's catalyst (0.1850 mmol; 129.9 mg). The flask was vacuumed and connected with a balloon of Hydrogen. The mixture was stirred at room temperature overnight. The mixture was filtered through Celite. The filtrate was concentrated. The residue was purified on silica eluted with 0 to 5% MeOH in DCM to afford 2-[[6-(5-ethyl-3-pyridyl)pyrazolo[4,3-c]pyridin-1-yl]methoxy]ethyl-trimethyl-silane (87 mg, 27%).

출처