반응 #860

반응 방정식

2-(2-methoxyethoxy)ethylamine

acetic acid

acetate

cyanamide

→

title compound

수율 28.5%

2-(2-methoxyethoxy)ethylguanidine

수율 28.5%

용매

반응 조건

후처리

1. 1
   기타After 5 hours of the reaction
2. 2
   기타the product was purified by a silica gel column chromatography (eluent, chloroform/ethanol=2/1 containing 0.5% acetic acid)

실험 절차

5.96 g (50.0 mmol) of 2-(2-methoxyethoxy)ethylamine and 3.00 g (50.0 mmol) of acetic acid were placed in a 30 ml two neck flask. While heating the flask in a 90° C. oil bath, 3.10 g (73.7 mmol) of cyanamide was added. After 5 hours of the reaction, the product was purified by a silica gel column chromatography (eluent, chloroform/ethanol=2/1 containing 0.5% acetic acid) to obtain 3.15 g of the title compound (wax-like, 14.2 mmol, 28.5% in yield) in the form of acetate. Results of the analysis of this compound are as follows.

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