반응 #85914

반응 방정식

4-bromo-N-methylaniline

K2CO3

2-bromoethanol

→

brown oil

수율 19.0%

2-((4-bromophenyl)(methyl)amino)ethanol

수율 19.0%

용매

DMF

반응 조건

후처리

1. 1
   기타The mixture was reacted at 100° C. for 2 days
2. 2
   추출Then it was extracted by EA and brine
3. 3
   세척washed by brine
4. 4
   건조dried over Na2SO4
5. 5
   농축concentrated
6. 6
   기타purified by flash chromatography, (PE: EA=10:1 to 3:1)

실험 절차

4-bromo-N-methylaniline (700 mg, 3.76 mmol) was dissolved in DMF (20 mL), K2CO3 (1.56 g, 11.29 mmol) and 2-bromoethanol (1.41 g, 11.29 mmol) were added in. The mixture was reacted at 100° C. for 2 days. Then it was extracted by EA and brine, washed by brine, dried over Na2SO4, concentrated and purified by flash chromatography, (PE: EA=10:1 to 3:1) to give 164 mg brown oil.

출처