반응 #85834

반응 방정식

water

tert-butyl piperazine-1-carboxylate

K2CO3

1,2-difluoro-4-nitrobenzene

→

tert-butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate

용매

DMF

반응 조건

후처리

1. 1
   추출extracted with EA (3×25 mL)
2. 2
   세척washed with H2O (25 mL) and brine (25 mL)
3. 3
   건조dried over Na2SO4
4. 4
   농축concentrated
5. 5
   기타to give yellow solid

실험 절차

To a solution of tert-butyl piperazine-1-carboxylate (1120 mg, 6 mmol) in DMF (25 mL) was added K2CO3 (828 mg, 6 mmol) and 1,2-difluoro-4-nitrobenzene (795 mg, 5 mmol) at room temperature. The reaction was stirred at 80° C. for 24 hours. After that, the reaction was poured into 50 mL of water and extracted with EA (3×25 mL), washed with H2O (25 mL) and brine (25 mL), dried over Na2SO4 and concentrated to give yellow solid. MS (m/z): 226 (M−99)+

출처