반응 #85806

반응 방정식

MeOH

Triisopropyl borate

5-bromo-N,N-dimethylpyridin-2-amine

n-BuLi

→

title compound

6-(dimethylamino)pyridin-3-ylboronic acid

용매

THF

반응 조건

후처리

1. 1
   workup.ADDITIONAfter the completion of the addition
2. 2
   온도slowly warmed up
3. 3
   workup.STIRRINGstirred at the ambient temperature overnight
4. 4
   기타the volatiles were removed under reduced pressure

실험 절차

A solution of 5-bromo-N,N-dimethylpyridin-2-amine (500 mg, 2.5 mmol) in THF (10 mL) was treated with n-BuLi (1.2 mL, 3 mmol) at −72° C. for 2 hours. Triisopropyl borate (705 mg, 3.75 mmol) was then added dropwise. After the completion of the addition, the mixture was stirred at −72° C. for an additional 1 hour and slowly warmed up and stirred at the ambient temperature overnight. MeOH was carefully added, and the volatiles were removed under reduced pressure to give the title compound. MS (m/z): 167 (M+H)+.

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