반응 #85793

반응 방정식

2,6-dichloropyridine-4-ylamine

nitric acid

→

title compound

N-(2,6-dichloropyridin-4-yl)nitramide

용매

sulfuric acid

반응 조건

후처리

1. 1
   기타the internal reaction temperature <10° C
2. 2
   기타the reaction temperature below 0° C.
3. 3
   기타of 40 minutes

실험 절차

2,6-dichloropyridine-4-ylamine (10.0 g, 61 mmol) was slowly added in concentrated sulfuric acid (64 mL) at the rate to keep the internal reaction temperature <10° C. The mixture was then cooled to −5° C. and nitric acid (90%, 30 mL) was added dropwise to keep the reaction temperature below 0° C. over a period of 40 minutes. The reaction mixture was stirred at 0° C. for 2 hours and then poured into ice-water (500 mL). The title compound was isolated by filtration and dried in vacuo for the next step.

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