반응 #85661

반응 방정식

Diphenylphosphine

2-(1-azidoethyl)-5-(4-chlorophenyl)-4-methyloxazole

→

1-(5-(4-chlorophenyl)-4-methyloxazol-2-yl)ethanamine

용매

methanol

반응 조건

후처리

1. 1
   여과The reaction was filtered
2. 2
   농축concentrated in vacuo
3. 3
   세척Flash column chromatography (silica, 40 g) eluting with 2-10% MeOH/DCM
4. 4
   기타afforded 160 mg (white solid)

실험 절차

SiliaBond® Diphenylphosphine (1500 mg, 1.19 mmol/g) was added to a solution of 2-(1-azidoethyl)-5-(4-chlorophenyl)-4-methyloxazole (366 mg, 1.393 mmol) in anhydrous methanol (15 ml) and shaken for 3 hours. The reaction was filtered and concentrated in vacuo. Flash column chromatography (silica, 40 g) eluting with 2-10% MeOH/DCM afforded 160 mg (white solid). HRMS(B) tR=1.73 min; MS m/z 236.0716

출처