반응 #8538

반응 방정식

Methyl 2-(2,3,4-trifluoroanilino)propionate

lithium hydroxide

→

title compound

수율 99.7%

2-(2,3,4-Trifluoroanilino)propionic acid

수율 99.7%

용매

methanol

반응 조건

후처리

1. 1
   기타at 0° C
2. 2
   기타the solvent was evaporated
3. 3
   workup.ADDITIONAfter adding water
4. 4
   세척the residue was washed with chloroform
5. 5
   workup.ADDITIONNext, hydrochloric acid (6 mol/l) was slowly added to the aqueous layer until pH value
6. 6
   추출Then the aqueous layer was extracted with diisopropyl ether (IPE)
7. 7
   건조The organic layer was dried over anhydrous magnesium sulfate
8. 8
   기타the solvent was evaporated

실험 절차

Methyl 2-(2,3,4-trifluoroanilino)propionate (46.64 g) was dissolved in methanol (130 ml) and an aqueous solution (3 mol/l; 100 ml) of lithium hydroxide was slowly added thereto at 0° C. After stirring at room temperature for 3 hours, the solvent was evaporated. After adding water, the residue was washed with chloroform. Next, hydrochloric acid (6 mol/l) was slowly added to the aqueous layer until pH value reached 1. Then the aqueous layer was extracted with diisopropyl ether (IPE). The organic layer was dried over anhydrous magnesium sulfate and then the solvent was evaporated to give the title compound (43.7 g) as colorless crystals.

출처