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acetic anhydride

3-chloro-1-(pyridin-3-yl)-1H-pyrazol-4-amine

acetyl chloride

acetic anhydride

→

N-(3-chloro-1-(pyridin-3-yl)-1H-pyrazol-4-yl)acetamide

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실험 절차

In step g of Scheme 1, 3-chloro-1-(pyridin-3-yl)-1H-pyrazol-4-amine (5d) is acylated with acetylating agents such as acetyl chloride or acetic anhydride, preferably acetic anhydride (Ac2O) to yield N-(3-chloro-1-(pyridin-3-yl)-1H-pyrazol-4-yl)acetamide (1c). The acylation is conducted in the presence of a base, preferably an inorganic base, such as, sodium bicarbonate (NaHCO3), and preferably, a polar solvent, such as ethyl acetate and/or tetrahydrofuran. This reaction may be conducted at temperatures from about −10° C. to about 30° C.

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