반응 #8535

반응 방정식

2,3,4-Trifluoronitrobenzene

pyruvic acid

→

title compound

수율 97.8%

2-(2,3,4-Trifluoroanilino)propionic acid

수율 97.8%

용매

IPA

반응 조건

후처리

1. 1
   여과After filtering off Pd—C
2. 2
   농축the obtained filtrate was concentrated under reduced pressure

실험 절차

2,3,4-Trifluoronitrobenzene (5.03 g) and pyruvic acid (2.75 g) were dissolved in IPA (40 ml). After adding 10% Pd—C (0.21 g), the mixture was stirred at 40° C. under a hydrogen gas pressure of 2.94 MPa for 3 hours. After filtering off Pd—C, the obtained filtrate was concentrated under reduced pressure. Thus the title compound (6.09 g) was obtained as colorless crystals. Various spectral data of this product was identical with those of a specimen synthesized separately.

출처