반응 #8534

반응 방정식

2,3,4-Trifluoronitrobenzene

pyruvic acid

hydrogen

→

title compound

수율 98.1%

2-(2,3,4-Trifluoroanilino)propionic acid

수율 98.1%

용매

isopropanol

반응 조건

후처리

1. 1
   여과After filtering off Pd—C
2. 2
   농축the obtained filtrate was concentrated under reduced pressure

실험 절차

2,3,4-Trifluoronitrobenzene (5.03 g) and pyruvic acid (2.75 g) were dissolved in isopropanol (IPA; 40 ml). After adding 10% Pd—C (0.21 g), the mixture was stirred at 40° C. under atmospheric pressure in a hydrogen atmosphere for 3 hours. After filtering off Pd—C, the obtained filtrate was concentrated under reduced pressure. Thus the title compound (6.11 g) was obtained as colorless crystals. Various spectral data of this product was identical with those of a specimen synthesized separately.

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