반응 #8532

반응 방정식

hydrochloric acid

2,3,4-Trifluoroaniline

methyl pyruvate

→

title compound

수율 95.8%

Methyl 2-(2,3,4-trifluoroanilino)propionate

수율 95.8%

용매

methanol

반응 조건

후처리

1. 1
   여과After filtering off Pd—C
2. 2
   농축the obtained filtrate was concentrated under reduced pressure

실험 절차

2,3,4-Trifluoroaniline (0.83 g) and methyl pyruvate (0.87 g) were dissolved in methanol (8 ml). After adding 5% Pd—C (0.11 g) and conc. hydrochloric acid (0.03 g), the mixture was stirred at 40° C. under a hydrogen gas pressure of 2.94 MPa for 2 hours. After filtering off Pd—C, the obtained filtrate was concentrated under reduced pressure. Thus the title compound (1.26 g) was obtained as slightly yellowish crystals. Various spectral data of this product was identical with those obtained in Example 5.

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