반응 #8531

반응 방정식

hydrochloric acid

2,3,4-Trifluoronitrobenzene

ethyl pyruvate

→

title compound

수율 97.9%

Ethyl 2-(2,3,4-trifluoroanilino)propionate

수율 97.9%

용매

ethanol

반응 조건

후처리

1. 1
   여과After filtering off Pd—C
2. 2
   농축the obtained filtrate was concentrated under reduced pressure

실험 절차

2,3,4-Trifluoronitrobenzene (1.01 g) and ethyl pyruvate (1.15 g) were dissolved in ethanol (8 ml). After adding 5% Pd—C (0.11 g) and conc. hydrochloric acid (0.03 g), the mixture was stirred at 40° C. under a hydrogen gas pressure of 2.94 MPa for 3 hours. After filtering off Pd—C, the obtained filtrate was concentrated under reduced pressure. Thus the title compound (1.38 g) was obtained as slightly yellow oily substance. Various spectral data of this product was identical with those obtained in Example 7.

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