반응 #8528

반응 방정식

hydrogen

2,3,4-Trifluoronitrobenzene

methyl pyruvate

ethanol

magnesium sulfate

→

title compound

Ethyl 2-(2,3,4-trifluoroanilino)propionate

용매

ethyl acetate normal hexane

반응 조건

후처리

1. 1
   여과After filtering off Pd—C and magnesium sulfate
2. 2
   농축the obtained filtrate was concentrated under reduced pressure
3. 3
   기타The residue thus obtained

실험 절차

2,3,4-Trifluoronitrobenzene (3.54 g) and methyl pyruvate (2.32 g) were dissolved in ethanol (30 ml). After adding 5% Pd—C (2.0 g) and anhydrous magnesium sulfate (2.65 g), the mixture was stirred at 50° C. in a hydrogen atmosphere for 16 hours. After filtering off Pd—C and magnesium sulfate, the obtained filtrate was concentrated under reduced pressure. The residue thus obtained was subjected to silica gel column chromatography (ethyl acetate-normal hexane=1:4) to give the title compound (4.84 g) as a pale yellow oily substance.

출처