반응 #8527

반응 방정식

hydrogen

2,3,4-Trifluoroaniline

methyl pyruvate

magnesium sulfate

→

title compound

수율 95.3%

Methyl 2-(2,3,4-trifluoroanilino)propionate

수율 95.3%

용매

methanol

반응 조건

후처리

1. 1
   여과After filtering off Pd—C and magnesium sulfate
2. 2
   농축the obtained filtrate was concentrated under reduced pressure
3. 3
   기타The crystals thus precipitated
4. 4
   여과were filtered
5. 5
   세척while washing with hexane

실험 절차

2,3,4-Trifluoroaniline (2.94 g) and methyl pyruvate (2.04 g) were dissolved in methanol (30 ml). After adding 5% Pd—C (2.0 g) and anhydrous magnesium sulfate (2.65 g), the mixture was stirred at 50° C. in a hydrogen atmosphere for 16 hours. After filtering off Pd—C and magnesium sulfate, the obtained filtrate was concentrated under reduced pressure. The crystals thus precipitated were filtered while washing with hexane. Thus the title compound (4.44 g) was obtained as slightly yellowish crystals. Various spectral data of this product was identical with those obtained in Example 5.

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