반응 #8525

반응 방정식

2,3,4-trifluoroaniline

potassium carbonate

methyl (2R)-2-[(methanesulfonyl)oxy]propionate

→

title compound

Methyl (2S)-2-(2,3,4-trifluoroanilino)propionate

반응 조건

후처리

1. 1
   기타In accordance with the process of Example 2, a condensation reaction

실험 절차

In accordance with the process of Example 2, a condensation reaction was performed by using 2,3,4-trifluoroaniline (100 mg), potassium carbonate (188 mg), methyl (2R)-2-[(methanesulfonyl)oxy]propionate (78 mg) and tetrahexylammonium chloride (40 mg) to give the title compound as an oily substance. As the result of the analysis by reversed phase HPLC with the use of the compound of Example 1 as a specimen, the product corresponded to 38 mg (24%) of the title compound.

출처