반응 #85028

반응 방정식

water dichloromethane

3,4-dihydro-2H-pyran

4-toluenesulphonic acid

6-methoxypyridin-3-ol

→

2-Methoxy-5-(tetrahydro-2H-pyran-2-yloxy)pyridine

용매

dichloromethane

반응 조건

후처리

1. 1
   추출the aqueous phase was extracted with dichloromethane
2. 2
   건조The combined organic phases were dried (sodium sulphate)
3. 3
   여과filtered
4. 4
   농축concentrated under reduced pressure

실험 절차

10.1 g (119.9 mmol, 1.5 eq.) of 3,4-dihydro-2H-pyran and 1.4 g (8.0 mmol, 0.1 eq.) of 4-toluenesulphonic acid were added to a solution of 10.0 g (79.9 mmol) of 6-methoxypyridin-3-ol in 150 ml of dichloromethane, and the mixture was stirred at RT for 5 d. After addition of water/dichloromethane and phase separation, the aqueous phase was extracted with dichloromethane. The combined organic phases were dried (sodium sulphate), filtered and concentrated under reduced pressure. Yield: 17.3 g (100% of theory)

출처