반응 #84924

ord-4304d1d4dacb420f9389b0f928691396

반응 방정식

CC(C(=O)OC(C)(C)C)n1ccc(-c2cc(Cl)ccc2Br)cc1=O
tert-butyl 2-[4-(2-bromo-5-chlorophenyl)-2-oxopyridin-1(2H)-yl]propanoate
O=C(O)C(F)(F)F
TFA
→
CC(C(=O)O)n1ccc(-c2cc(Cl)ccc2Br)cc1=O
2-[4-(2-Bromo-5-chlorophenyl)-2-oxopyridin-1(2H)-yl]propanoic acid

반응물

CC(C(=O)OC(C)(C)C)n1ccc(-c2cc(Cl)ccc2Br)cc1=O
tert-butyl 2-[4-(2-bromo-5-chlorophenyl)-2-oxopyridin-1(2H)-yl]propanoate
O=C(O)C(F)(F)F
TFA

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

920 mg (2.2 mmol) of tert-butyl 2-[4-(2-bromo-5-chlorophenyl)-2-oxopyridin-1(2H)-yl]propanoate (racemate) were hydrolysed with TFA according to General Method 6A. Yield: 1110 mg (purity 93%, quant.)

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US09434690B2uspto-grants-2016_09