반응 #84864

반응 방정식

NaHCO3

1-(4-bromo-3,5-dimethoxyphenyl)propan-1-one

pyridinium tribromide

→

2-bromo-1-(4-bromo-3,5-dimethoxyphenyl)propan-1-one

수율 56.4%

용매

THF

반응 조건

후처리

1. 1
   추출The mixture was extracted with EtOAc the combined
2. 2
   세척organics were washed with saturated aqueous NaHCO3 and brine
3. 3
   건조then dried over Na2SO4
4. 4
   농축concentrated in vacuo
5. 5
   기타Purification by chromatography (10-20% EtOAc-hexanes)

실험 절차

To a solution of 1-(4-bromo-3,5-dimethoxyphenyl)propan-1-one (1.50 g, 5.49 mmol) in anhydrous THF (20 mL) was added pyridinium tribromide (1.93 g, 6.04 mmole). The reaction was stirred at room temperature for 2 hrs then neutralized with a solution of saturated aqueous NaHCO3. The mixture was extracted with EtOAc the combined organics were washed with saturated aqueous NaHCO3 and brine then dried over Na2SO4 and concentrated in vacuo. Purification by chromatography (10-20% EtOAc-hexanes) gave 2-bromo-1-(4-bromo-3,5-dimethoxyphenyl)propan-1-one as an orange oil (1.09 g, 56% yield).

출처