반응 #84824

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5-Bromo-2-(difluoromethoxy)-1,3-dimethoxybenzene

2-furylboronic acid

→

2-(4-(difluoromethoxy)-3,5-dimethoxyphenyl)furan

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후처리

1. 1
   기타for the synthesis of Example 21
2. 2
   기타Purification by chromatography (0-30% EtOAc-hexanes)

실험 절차

5-Bromo-2-(difluoromethoxy)-1,3-dimethoxybenzene was coupled with 2-furylboronic acid following the procedure for the synthesis of Example 21. Purification by chromatography (0-30% EtOAc-hexanes) provided 2-(4-(difluoromethoxy)-3,5-dimethoxyphenyl)furan as a white crystalline material (0.555 g, 67% yield).

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