반응 #84816

반응 방정식

4-Bromo-2,6-dimethoxyphenol

2-furylboronic acid

→

4-(furan-2-yl)-2,6-dimethoxyphenol

수율 79.0%

반응 조건

후처리

1. 1
   기타used in the synthesis of Example 21
2. 2
   기타Purification by chromatography (20-40% EtOAc-hexanes)

실험 절차

4-Bromo-2,6-dimethoxyphenol (Lee, H.; et al. Tetrahedron Letters, 2004, 45, 1019) was coupled with 2-furylboronic acid according to the procedure used in the synthesis of Example 21. Purification by chromatography (20-40% EtOAc-hexanes) gave 4-(furan-2-yl)-2,6-dimethoxyphenol as a light orange solid (1.95 g, 79% yield).

출처