반응 #84808

반응 방정식

N,2-dimethoxy-N-methyl-2-(quinolin-5-yl)acetamide

2-(4-bromo-3,5-dimethoxyphenyl)furan

→

1-(5-(4-bromo-3,5-dimethoxyphenyl)furan-2-yl)-2-methoxy-2-(quinolin-5-yl)ethanone

수율 46.0%

반응 조건

후처리

1. 1
   기타used for the synthesis of Example 12
2. 2
   기타Purification by chromatography (EtOAc-hexanes)

실험 절차

1-(5-(4-Bromo-3,5-dimethoxyphenyl)furan-2-yl)-2-methoxy-2-(quinolin-5-yl)ethanone was synthesized from N,2-dimethoxy-N-methyl-2-(quinolin-5-yl)acetamide and 2-(4-bromo-3,5-dimethoxyphenyl)furan following the procedure used for the synthesis of Example 12. Purification by chromatography (EtOAc-hexanes) provided 1-(5-(4-bromo-3,5-dimethoxyphenyl)furan-2-yl)-2-methoxy-2-(quinolin-5-yl)ethanone as a light yellow foam (0.102 g, 46% yield). MS: m/z 482.1 [M+H]+.

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