반응 #84798

반응 방정식

KOH

4-(5-ethyl-1,3,4-oxadiazol-2-yl)benzaldehyde

CHCl3

→

2,2,2-trichloro-1-(4-(5-ethyl-1,3,4-oxadiazol-2-yl)phenyl)ethanol

수율 80.0%

용매

MeOH

DMF

반응 조건

후처리

1. 1
   기타the reaction mixture was quenched with 1 M HCl
2. 2
   기타The solid formed
3. 3
   기타was collected on a Buchner
4. 4
   세척washed with H2O
5. 5
   기타dried under vacuum

실험 절차

To a solution of 4-(5-ethyl-1,3,4-oxadiazol-2-yl)benzaldehyde (1.6 g, 7.9 mmol) in anhydr DMF (7 mL) was added CHCl3 (2.13 g, 17.8 mmol). After cooling to −10° C., a solution of KOH (0.31 g, 5.5 mmol) in anhydr MeOH (1.5 mL) was added dropwise over 20 min. After stirring at −10° C. for 1 hr, the reaction mixture was quenched with 1 M HCl. The solid formed was collected on a Buchner, washed with H2O and dried under vacuum to give 2,2,2-trichloro-1-(4-(5-ethyl-1,3,4-oxadiazol-2-yl)phenyl)ethanol as a white solid (2.0 g, 80% yield).

출처