반응 #84710

반응 방정식

2,2-dimethyl-3,6-dihydro-2H-pyran

3-chloroperoxybenzoic acid

→

title compound

수율 108.4%

4,4-dimethyl-3,7-dioxa-bicyclo[4.1.0]heptane

수율 108.4%

용매

dichloromethane

dichloromethane

반응 조건

후처리

1. 1
   세척washed with saturated aqueous sodium sulfite and brine
2. 2
   건조The organic layer was dried over sodium sulfate
3. 3
   여과filtered
4. 4
   농축concentrated under reduced pressure

실험 절차

To a solution of 2,2-dimethyl-3,6-dihydro-2H-pyran (4.0 g, 36 mmol) in dichloromethane (20 mL) was added 3-chloroperoxybenzoic acid (18.4 g, 107 mmol), and the mixture was stirred at room temperature overnight. The reaction mixture was then diluted with dichloromethane, and washed with saturated aqueous sodium sulfite and brine. The organic layer was dried over sodium sulfate, filtered, and concentrated under reduced pressure to give the title compound (5.0 g, crude) as a yellow oil, which was directly used in the next step without further purification.

출처