반응 #8467

반응 방정식

product

alpha-bromo-3′-methoxy-4′-chloropropoxyacetophenone

2-amino-4-picoline

→

title compound

수율 70.5%

2-(4′-chloropropoxy-3′-methoxyphenyl)-7-methylimidazo[1,2-a]pyridine hydrobromide

수율 70.5%

용매

ethanol

반응 조건

후처리

1. 1
   기타evaporated to a yellow solid
2. 2
   여과The mixture was filtered
3. 3
   기타the solid product collected

실험 절차

A solution of the product of Step B (1.44 g) and 2-amino-4-picoline (0.486 g) in ethanol (6 mL) was heated at 73° C. for 1 hour. The reaction mixture was cooled to ambient temperature and evaporated to a yellow solid. The solid was stirred with 25 mL of dichloromethane for approximately 10 minutes. The mixture was filtered and the solid product collected to yield the title compound (1.3 g).

출처