반응 #84576

반응 방정식

4-(2,6-difluoro-4-nitrophenyl)morpholine

THF

→

title compound

수율 88.0%

3,5-difluoro-4-morpholinoaniline

수율 88.0%

용매

ethanol

반응 조건

후처리

1. 1
   여과The mixture was filtered
2. 2
   농축concentrated in vacuo
3. 3
   기타the residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=8:1)

실험 절차

A mixture of 4-(2,6-difluoro-4-nitrophenyl)morpholine (4.71 g, 19.3 mmol), THF (30 mL), ethanol (30 mL) and Pd/C (2.0 g, 10%) was stirred at rt under H2 overnight. The mixture was filtered and concentrated in vacuo and the residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=8:1) to give the title compound as a yellow solid (3.62 g, 88%).

출처