반응 #84572

반응 방정식

3-fluorophenol

ethyl 2-bromo-2,2-difluoroacetate

K2CO3

→

title compound

ethyl 2,2-difluoro-2-(3-fluorophenoxy)acetate

용매

MeOH

반응 조건

후처리

1. 1
   온도It was then cooled to rt
2. 2
   여과filtered
3. 3
   농축the filtrate was concentrated in vacuo

실험 절차

A mixture of 3-fluorophenol (2.24 g, 20.0 mmol), ethyl 2-bromo-2,2-difluoroacetate (8.12 g, 40.0 mmol) and K2CO3 (6.91 g, 50.0 mmol) in MeOH (20 mL) was stirred at 70° C. overnight. It was then cooled to rt and filtered and the filtrate was concentrated in vacuo to give the title compound, which was used for next step without further purification.

출처