반응 #84561

반응 방정식

3-hydroxybenzonitrile

2-bromoacetamide

K2CO3

→

title compound

수율 77.0%

2-(3-cyanophenoxy)acetamide

수율 77.0%

용매

acetone

반응 조건

후처리

1. 1
   온도The mixture was cooled to rt
2. 2
   여과filtered
3. 3
   농축the filtrate was concentrated in vacuo
4. 4
   기타The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:1)

실험 절차

A mixture of 3-hydroxybenzonitrile (2.38 g, 20.0 mmol), 2-bromoacetamide (3.04 g, 22.0 mmol) and K2CO3 (5.53 g, 40.0 mmol) in acetone (20 mL) was stirred at 70° C. for 17.5 h. The mixture was cooled to rt and filtered and the filtrate was concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:1) to give the title compound as a white solid (2.70 g, 77%).

출처