반응 #84537

반응 방정식

2-bromoethanol

morpholine

K2CO3

→

title compound

수율 83.4%

2-morpholinoethanol

수율 83.4%

용매

CH3CN

반응 조건

후처리

1. 1
   온도was refluxed for 3 h
2. 2
   여과filtered
3. 3
   농축The filtrate was concentrated in vacuo

실험 절차

A mixture of 2-bromoethanol (27.9 g, 223 mmol), morpholine (40 g, 459 mmol) and K2CO3 (48.4 g, 350 mmol) in CH3CN (30 mL) was refluxed for 3 h. The mixture was then cooled to rt and filtered. The filtrate was concentrated in vacuo to give the title compound as a yellow solid (24.40 g, 83%), which was used for next step without further purification.

출처