반응 #84514

반응 방정식

(Z)-3-amino-N-(3-trifluoromethyl-4-morpholinophenyl)but-2-enamide

triethyl orthoacetate

→

title compound

수율 70.0%

3-(3-trifluoromethyl-4-morpholinophenyl)-2,6-dimethylpyrimidin-4(3H)-one

수율 70.0%

반응 조건

후처리

1. 1
   온도The mixture was cooled to rt
2. 2
   농축concentrated in vacuo
3. 3
   기타The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:1)

실험 절차

A mixture of (Z)-3-amino-N-(3-trifluoromethyl-4-morpholinophenyl)but-2-enamide (4.0 g, 12.1 mmol) and triethyl orthoacetate (10 mL) was stirred at 150° C. overnight. The mixture was cooled to rt and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:1) to give the title compound as a pale yellow solid (3.00 g, 70%). The compound was characterized by the following spectroscopic data:

출처