반응 #8447

ord-81cf14fa4bba449a837dcc91caaa551b

반응 방정식

COc1ccc(N(Cc2ccc(C)cc2)Cc2ccc(C)cc2)cc1NC(=S)NC(=O)c1ccccc1
1-benzoyl-3-{5-[bis-(4-methyl-benzyl)-amino]-2-methoxy-phenyl}-thiourea
Br.CC(=O)O
HBr AcOH
CS(C)=O
DMSO
→
COc1ccc(N(Cc2ccc(C)cc2)Cc2ccc(C)cc2)c2sc(NC(=O)c3ccccc3)nc12
N-{7-[Bis-(4-methyl-benzyl)-amino]-4-methoxy-benzothiazol-2-yl}-benzamide

반응물

COc1ccc(N(Cc2ccc(C)cc2)Cc2ccc(C)cc2)cc1NC(=S)NC(=O)c1ccccc1
1-benzoyl-3-{5-[bis-(4-methyl-benzyl)-amino]-2-methoxy-phenyl}-thiourea
Br.CC(=O)O
HBr AcOH
CS(C)=O
DMSO

시약

없음

용매

CC(=O)O
AcOH

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

From 1-benzoyl-3-{5-[bis-(4-methyl-benzyl)-amino]-2-methoxy-phenyl}-thiourea with HBr—AcOH (2 equiv.) and DMSO (1.1 equiv.) in AcOH. ES-MS m/e (%): 508 (M+H+, 100).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07087761B2uspto-grants-2006_08