반응 #84419

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N,N-di-n-butyl-2-fluoro-4-nitroaniline

CH2Cl2

→

title compound

수율 65.0%

N1,N1-di-n-butyl-2-fluorobenzene-1,4-diamine

수율 65.0%

용매

MeOH

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후처리

1. 1
   여과filtered
2. 2
   농축The filtrate was concentrated in vacuo
3. 3
   기타The residue was purified by a silica gel column chromatography (PE/CH2Cl2 (V/V)=8:1)

실험 절차

To a solution of N,N-di-n-butyl-2-fluoro-4-nitroaniline (4.03 g, 15 mmol) in mixed solvents of CH2Cl2 (70 mL) and MeOH (20 mL) was added catalyst Pd/C (0.40 g). The reaction mixture was stirred at rt under H2 overnight, and filtered. The filtrate was concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/CH2Cl2 (V/V)=8:1) to give the title compound as colorless oil (2.32 g, 65%).

출처