반응 #84406

반응 방정식

1,2-difluoro-4-nitrobenzene

K2CO3

pyrrole

→

title compound

수율 97.0%

1-(2-fluoro-4-nitrophenyl)-1H-pyrrole

수율 97.0%

용매

DMSO

water

반응 조건

후처리

1. 1
   온도cooled to rt
2. 2
   여과filtered
3. 3
   기타the filter cake was dried

실험 절차

To a solution of 1,2-difluoro-4-nitrobenzene (1.59 g, 10 mmol) in DMSO (15 mL) were added K2CO3 (3.04 g, 22 mmol) and pyrrole (0.74 g, 11 mmol) with stirring. The reaction mixture was heated at 90° C. for 18 h, and cooled to rt. The mixture was diluted with water (50 mL), filtered and the filter cake was dried to give the title compound as a yellow solid (2.00 g, 97%).

출처