반응 #84390

반응 방정식

N,N-diethyl-4-(5-nitrothiazol-2-yl)aniline

→

title compound

수율 69.0%

2-(4-(diethylamino)phenyl)thiazol-5-amine

수율 69.0%

용매

MeOH

반응 조건

후처리

1. 1
   여과filtered
2. 2
   농축The filtrate was concentrated in vacuo
3. 3
   기타The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=5:1)

실험 절차

To a solution of N,N-diethyl-4-(5-nitrothiazol-2-yl)aniline (0.73 g, 2.64 mmol) in MeOH (30 mL) was added Pd/C (73 mg). The reaction mixture was stirred at rt under H2 overnight, then filtered. The filtrate was concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=5:1) to give the title compound as a white solid (0.45 g, 69%).

출처