반응 #84387

반응 방정식

4-(diethylamino)benzamide

P2S5

→

title compound

수율 20.1%

4-(diethylamino)benzothioamide

수율 20.1%

용매

THF

반응 조건

후처리

1. 1
   온도cooled to rt
2. 2
   여과filtered
3. 3
   농축the filtrate was concentrated in vacuo
4. 4
   기타The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=2:1)

실험 절차

To a solution of 4-(diethylamino)benzamide (5.66 g, 29.43 mmol) in THF (80 mL) was added P2S5 (9.81 g, 44.14 mmol) at 50° C. over a period of 1 h. The mixture was heated at 55° C. for 8 h, then cooled to rt, filtered and the filtrate was concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=2:1) to give the title compound as a yellow solid (1.23 g, 20%).

출처