반응 #84340

반응 방정식

1-[3-chloro-5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethanone

triethylphenylammonium tribromide

→

desired crude product

수율 189.3%

2-bromo-1-[3-chloro-5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethanone

수율 189.3%

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   기타After completion of the reaction
2. 2
   여과the precipitated solid was filtered off through celite
3. 3
   기타the solvent was evaporated under reduced pressure

실험 절차

To 1.1 g of 1-[3-chloro-5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethanone in 20 ml of tetrahydrofuran, 1.6 g of triethylphenylammonium tribromide was added, and the mixture was stirred at room temperature for 12 hours. After completion of the reaction, the precipitated solid was filtered off through celite, and the solvent was evaporated under reduced pressure to obtain 1.3 g of the desired crude product as a pale yellow oil. The oil was used in the next step without further purification.

출처