반응 #84283

반응 방정식

1-(3-chloro-5-methoxypyridin-2-yl)ethanone

trimethylphenylammonium tribromide

→

desired product

수율 76.8%

2-bromo-1-(3-chloro-5-methoxypyridin-2-yl)ethanone

수율 76.8%

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   기타After completion of the reaction
2. 2
   여과the precipitated solid was filtered off
3. 3
   기타the solvent was evaporated under reduced pressure
4. 4
   기타The resulting residue was purified by silica gel column chromatography

실험 절차

To 0.90 g of 1-(3-chloro-5-methoxypyridin-2-yl)ethanone in 10 ml of tetrahydrofuran, 1.82 g of trimethylphenylammonium tribromide was added, and the mixture was stirred at room temperature for 16 hours. After completion of the reaction, the precipitated solid was filtered off, and the solvent was evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography using ethyl acetate-hexane (with a gradient of from 1:9 to 3:7) as the eluent to obtain 0.57 g of the desired product as pale yellow crystals.

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