반응 #84170

반응 방정식

58

Methanesulfonic acid 5-bromo-3-methanesulfonyloxymethyl-pyridin-2-ylmethyl ester

MeOH NH3

→

desired compound

3-Bromo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine

용매

MeOH

반응 조건

후처리

1. 1
   기타The reaction mixture was evaporated

실험 절차

To a solution of 58 (1 g, crude) in MeOH (5 mL) was added MeOH—NH3 (5 mL) at 0° C. and stirred at rt for overnight. The reaction mixture was evaporated to obtain the desired compound (600 mg, crude) as a brown liquid. Rf: 0.2 (10% MeOH/CHCl3). The crude compound was used in the next step without further purification; (m/z): 199, 201 [MH]+.

출처